منابع مشابه
Influenza virus assembly and budding.
Influenza A virus causes seasonal epidemics, sporadic pandemics and is a significant global health burden. Influenza virus is an enveloped virus that contains a segmented negative strand RNA genome. Assembly and budding of progeny influenza virions is a complex, multi-step process that occurs in lipid raft domains on the apical membrane of infected cells. The viral proteins hemagglutinin (HA) a...
متن کاملAssembly and budding of influenza virus.
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family. These viruses possess segmented, negative stranded RNA genomes (vRNA) and are enveloped, usually spherical and bud from the plasma membrane (more specifically, the apical plasma membrane of polarized epithelial cells). Complete viru...
متن کاملDual Function of CD81 in Influenza Virus Uncoating and Budding
As an obligatory pathogen, influenza virus co-opts host cell machinery to harbor infection and to produce progeny viruses. In order to characterize the virus-host cell interactions, several genome-wide siRNA screens and proteomic analyses have been performed recently to identify host factors involved in influenza virus infection. CD81 has emerged as one of the top candidates in two siRNA screen...
متن کاملAlterations of membrane curvature during influenza virus budding.
Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and mortality worldwide, and have a significant financial impact on society. Assembly and budding of new viral particles are a complex and multi-step p...
متن کاملInfluenza A virus lures autophagic protein LC3 to budding sites.
Autophagy, a cellular degradation pathway, can restrict or assist viral replication. In this issue of Cell Host & Microbe, Beale et al. (2014) report that the influenza virus matrix protein 2 binds to the essential autophagy protein LC3 to presumably transport LC3-conjugated membranes to the cell surface for budding of stable viruses.
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ژورنال
عنوان ژورنال: Virus Research
سال: 2009
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2009.05.010